I've been working with the awesome Xamarin.Forms recently which was working just fine. I then needed to deploy a WCF service into my local IIS (my usual preference to IIS Express) for some testing. The virtual directory was created fine by Visual Studio, but I could not access the .SVC page.
It took a few minutes of deep thought to consider what was happening. It was a fairly new Windows 10 machine that had IIS installed, but, Windows is now very locked own out-of-the-box, so I realised that it still didn't have the features needed to activate a WCF service!
If you open Programs and Features and then Add/Remove Windows features you can add WCF Activation and the WCF services you require. I also ran aspnet_Regiis.exe -i to be sure that my .NET versions were all correctly registered for use by IIS.
Once I installed the Windows features, everything started working fine. Hope this helps!